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KMID : 0811720140180050441
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Korean Journal of Physiology & Pharmacology
2014 Volume.18 No. 5 p.441 ~ p.446
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Ursolic Acid-Induced Elevation of Serum Irisin Augments Muscle Strength During Resistance Training in Men
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Bang Hyun-Seok
Seo Dae-Yun
Chung Yong-Min
Oh Kyoung-Mo
Park Jung-Jun
Arturo Figueroa
Jung Seung-Hun
Kim Na-Ri
Han Jin
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Abstract
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Ursolic acid (UA), a type of pentacyclic triterpenoid carboxylic acid purified from natural plants, can promote skeletal muscle development. We measured the effect of resistance training (RT) with/without UA on skeletal muscle development and related factors in men. Sixteen healthy male participants (age, 29.37±5.14 years; body mass index=27.13±2.16 kg/m2) were randomly assigned to RT (n=7) or RT with UA (RT+UA, n=9) groups. Both groups completed 8 weeks of intervention consisting of 5 sets of 26 exercises, with 10∼15 repetitions at 60∼80% of 1 repetition maximum and a 60∼90-s rest interval between sets, performed 6 times/week. UA or placebo was orally ingested as 1 capsule 3 times/day for 8 weeks. The following factors were measured pre-and post-intervention: body composition, insulin, insulin-like growth factor-1 (IGF-1), irisin, and skeletal muscle strength. Body fat percentage was significantly decreased (p＜0.001) in the RT+UA group, despite body weight, body mass index, lean body mass, glucose, and insulin levels remaining unchanged. IGF-1 and irisin were significantly increased compared with baseline levels in the RT+UA group (p＜0.05). Maximal right and left extension (p＜0.01), right flexion (p＜0.05), and left flexion (p＜0.001) were significantly increased compared with baseline levels in the RT+UA group. These findings suggest that UA-induced elevation of serum irisin may be useful as an agent for the enhancement of skeletal muscle strength during RT.
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KEYWORD
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IGF-1, Irisin, Muscle strength, Resistance training, Ursolic acid
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